Magnetic Particle Imaging

Magnetic particle imaging (MPI) is an emerging molecular imaging modality that enables non-invasive, tomographic, unambiguous, sensitive, and quantitative imaging of the distribution of superparamagnetic iron oxide nanoparticles (SPIONs) in a living subject. MPI signal is not attenuated by tissue and arises solely from exogenous SPIONs that are biocompatible and biodegradable. While MPI is relatively new, rapid progress towards clinical translation is taking place and there much excitement over applications in blood pool imaging, molecular imaging of disease markers, and quantitative tracking of nanomedicines and cell therapies. Rinaldi-Ramos’s lab is making fundamental contributions to understanding the role of SPION relaxation mechanisms and interactions on their MPI performance. In collaboration with Steve Conolly, one of the pioneers of the field of MPI, Rinaldi-Ramos’s lab has demonstrated MPI guided and spatially controlled hyperthermia using SPIONs. Furthermore, Rinaldi-Ramos’s lab has developed new SPION synthesis techniques that yield nearly defect free nanoparticles with enhanced MPI performance. These unique SPIONs are being formulated for applications in drug delivery, cell tracking, and organ cryopreservation.

Related Publications

  • Andreina Chiu LamG, Edward Staples, Carl Pepine, and Carlos Rinaldi, “Perfusion, cryopreservation, and nanowarming of whole hearts using colloidally stable cryopreservation agent solutions.” Science Advances, 7(2):eabe3005, 2021. []
  • Yao Lu, Angelie Rivera-RodriguezG, Zhi Wei Tay, Daniel Hensley, K.L. Barry Fung, Caylin Colson, Chinmoy Saayujya, Quincy Huynh, Leyla Kabuli, Benjamin Fellows, Prashant Chandrasekharan, Carlos Rinaldi, and Steven Conolly, “Combining magnetic particle imaging and magnetic hyperthermia for localized and image-guided treatment.” International Journal of Hyperthermia, 37(3):141-154, 2020. []
  • Zhiyuan ZhaoG and Carlos Rinaldi, “Computational predictions of enhanced magnetic particle imaging performance by magnetic nanoparticle chains.” Physics in Medicine and Biology, 65:185013, 2020. []
  • Nathanne C.V. RostF, Kacoli SenP, Ishita SinghG, Leando Raniero, and Carlos Rinaldi, “Magnetic particle imaging performance of liposomes encapsulating iron oxide nanoparticles.” Journal of Magnetism and Magnetic Materials, 504:166675, 2020. []
  • Zhiyuan ZhaoG, Nicolas Garraud, David Arnold, and Carlos Rinaldi, “Effects of particle diameter and magnetocrystalline anisotropy on magnetic relaxation and magnetic particle imaging performance of magnetic nanoparticles.” Physics in Medicine and Biology, 65(2):025014, 2020. []
  • Prashant Chandrasekharan, Zhi Wei Tay, Daniel Hensley, Xinyi Y Zhou, Barry KL Fung, Caylin Colson, Yao Lu, Benjamin D Fellows, Quincy Huynh, Chinmoy Saayujya, Elaine Yu, Ryan Orendorff, Zheng Bo, Patrick Goodwill, Carlos Rinaldi, and Steven Conolly, “Using magnetic particle imaging systems to localize and guide magnetic hyperthermia treatment: Tracers, hardware, and future medical applications.” Theranostics, 10(7):2965, 2020. []
  • Eric Fuller*G, Georg M. Scheutz*, Angela JimenezU, Parker LewisU, Shehaab SavliwalaG, Sitong LiuG, Brent S. Sumerlin, and Carlos Rinaldi, “Theranostic nanocarriers combining high drug loading and magnetic particle imaging.” International Journal of Pharmaceutics, 572, 118796, 2019. []
  • Nicolas Garraud, Rohan DhavalikarG, Mythreyi UnniG, Shehaab SavliwalaG, David P. Arnold, and Carlos Rinaldi, “Benchtop magnetic particle relaxometer for detection, characterization, and analysis of magnetic nanoparticles.” Physics in Medicine and Biology, 63:175016, 2018. []
  • Zhi Wei Tay, Prashant Chandrasekharan, Andreina Chiu-LamG, Daniel Hensley, Rohan DhavalikarG, Xinyi Zhou, Elaine Yu, Patrick Goodwill, Bo Zheng, Carlos Rinaldi, Steven M. Conolly, “Magnetic Particle Imaging Guided Heating In Vivo using Gradient Fields For Arbitrary Localization of Thermal Therapy.” ACS Nano, 12(4):3699-3713, 2018. []
  • Nicolas Garraud, Rohan DhavalikarG, Lorena Maldonado-CamargoG, David P. Arnold, and Carlos Rinaldi, “Design and Validation of Magnetic Particle Spectrometer for Characterization of Magnetic Nanoparticle Relaxation Dynamics.” AIP Advances, 7:056730, 2017. []
  • Daniel Hensley, Zhi Wei Tay, Rohan DhavalikarG, Bo Zheng, Patrick Goodwill, Carlos Rinaldi, Steven Conolly, “Combining Magnetic Particle Imaging and magnetic fluid hyperthermia in a theranostic platform.” Physics in Medicine and Biology, 62(9):3483, 2017. []
  • Mythreyi UnniG, Amanda Uhl, Shehaab SavliwalaG, Benjamin Savitzky, Rohan DhavalikarG, Nicolas Garraud, David Arnold, Lena Kourkoutis, Jennifer Andrew, and Carlos Rinaldi, “Thermal decomposition synthesis of iron oxide nanoparticles with diminished magnetic dead layer by controlled addition of oxygen.” ACS Nano, 11(2):2284-2303, 2017. []
  • Rohan DhavalikarG and Carlos Rinaldi, “Theoretical Predictions for the Spatial Distribution of Magnetic Nanoparticle Heating in Magnetic Particle Imaging Field Gradients.” Journal of Magnetism and Magnetic Materials, 419:267-273, 2016. []
  • Rohan DhavalikarG, Lorena P. Maldonado-CamargoG, Daniel Hensley, Patrick S. Goodwill, Steven M. Conolly, and Carlos Rinaldi, “Finite magnetic relaxation in X-Space magnetic particle imaging: Comparison of measurements and ferrohydrodynamic modeling.” Journal of Physics D, 49(30):305002, 2016. []
  • Rohan DhavalikarG, Nicolas Garraud, and Carlos Rinaldi, “Ferrohydrodynamic modeling of magnetic nanoparticle harmonic spectra for magnetic particle imaging.” Journal of Applied Physics, 118:173906, 2015. [, PMID: 26576063]
  • Rohan DhavalikarG and Carlos Rinaldi, “On the effect of finite magnetic relaxation on the magnetic particle imaging performance of magnetic nanoparticles.” Journal of Applied Physics, 115:074308, 2014. []