Carlos Rinaldi » Biomolecular and Cellular Engineering for Human Health

Jang LabWe perform fundamental research and develop technologies for improving human health. Ongoing research includes studies of nanoparticle-biological interactions, cellular mechanics, engineering of proteases and CRISPR-Cas systems, development of new types of sensors, and new materials for biomedical applications.

Faculty

Photo of Carlos Rinaldi

Carlos Rinaldi

Department Chair and Dean’s Leadership Professor
Work Office: CHE SC 289 Lab: CHE 333 and 337 1030 Center Drive Gainesville FL 32611 Work Phone: (352) 392-0881 Website: Rinaldi Research Laboratory

Biography

MY GROUP STUDIES THE BEHAVIOR AND BIOMEDICAL APPLICATIONS OF MAGNETIC NANOPARTICLES. The response of magnetic nanoparticles to applied magnetic fields enables a broad range of biomedical applications, such as imaging agents for magnetic resonance and magnetic particle imaging, biosensors, targeted delivery and triggered release of drugs, magnetomechanical actuation of cell response, and nanoscale thermal therapy. We combine expertise in synthesis and surface modification of magnetic nanoparticles; physical, chemical, and magnetic characterization; and modelling to answer fundamental and applied questions regarding the behavior of magnetic nanoparticles, understand their interaction with biological entities, and advance their biomedical applications. We are actively investigating novel methods of synthesizing nanoparticles with tailored magnetic properties, evaluating nanoparticle stability and mobility in biological environments, and advancing applications of magnetic nanoparticles in cancer therapy and magnetic particle imaging.

MAGNETIC PARTICLE IMAGING

Magnetic particle imaging (MPI) is a new biomedical imaging modality that enables unambiguous, tomographic, and quantitative evaluation of the distribution of magnetic nanoparticles in living subjects. My group is engineering biocompatible nanoparticle tracers for MPI that offer unprecedented resolution and sensitivity and can be used to track cells or image the distribution of biomarkers in pre-clinical models of cancer, arthritis, and diabetes. We are also engineering the surface of these tracers for labelling cells of the innate and adaptive immune system to enable sensitive and quantitative tracking of their biodistribution. We collaborate with clinicians and other scientists to evaluate the application of MPI for tracking adoptive cell transfer immunotherapies.

Education

Ph.D., Massachusetts Institute of Technology, 2002
M.S.C.E.P., Massachusetts Institute of Technology, 2001
M.S., Massachusetts Institute of Technology, 2001
B.Sc., University of Puerto Rico, Mayagüez, 1998

Awards & Distinctions

  • Fellow, American Institute for Medical and Biological Engineering (AIMBE), 2020
  • University of Florida Term Professors, 2017-2020
  • Charles A. Stokes Term Professor, University of Florida, 2015-2018
  • International Journal of Nanomedicine Early Career Award, 2012
  • Presidential Early Career Award for Scientists and Engineers (PECASE), 2006

selected Publications

  • Lorena P. Maldonado-Camargo, Chuncheng Yang, and Carlos Rinaldi, “Scale-dependent rotational diffusion of nanoparticles in polymer solutions.” Nanoscale, 9(33):12039-12050, 2017. [doi:10.1039/C7NR01603D]
  • Mythreyi Unni, Amanda Uhl, Shehaab Savliwala, Benjamin Savitzky, Roham Dhavalikar, Nicolas Garraud, David Arnold, Lena Kourkoutis, Jennifer Andrew, and Carlos Rinaldi, “Thermal decomposition synthesis of iron oxide nanoparticles with diminished magnetic dead layer by controlled addition of oxygen.” ACS Nano, 11(2):2284-2303, 2017. [doi: 10.1021/acsnano.7b00609]
  • Lorena P. Maldonado-Camargo and Carlos Rinaldi, “Breakdown of the Stokes-Einstein relation for the rotational diffusivity of polymer grafted nanoparticles in polymer melts.” Nano Letters, 16:6767-6773, 2016. [doi: 10.1021/acs.nanolett.6b02359]
  • Camilo Velez, Isaac Torres-Díaz, L.P. Maldonado-Camargo, Carlos Rinaldi, and David P. Arnold, “Magnetic assembly and crosslinking of nanoparticles for releasable magnetic microstructures.” ACS Nano, 9(10):10165-10172, 2015. [doi: 10.1021/acsnano.5b03783]
  • Maribella Domenech, Ileana Marrero-Berrios, Madeline Torres-Lugo, and Carlos Rinaldi, “Lysosomal Membrane Permeabilization by Targeted Magnetic Nanoparticles in Alternating Magnetic Fields.” ACS Nano, 7(6):5091-5101, 2013. [doi: 10.1021/nn4007048]
  • Mar Creixell, Ana C. Bohorquez, Madeline Torres-Lugo, and Carlos Rinaldi, “EGFR-targeted magnetic nanoparticle heaters can kill cancer cells without a perceptible temperature rise.” ACS Nano, 5(9), 7124-7129, 2011. [doi: 10.1021/nn201822b]
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Office: CHE SC 289 Lab: CHE 333 and 337 Gainesville FL 32611