We perform fundamental research and develop technologies for improving human health. Ongoing research includes studies of nanoparticle-biological interactions, cellular mechanics, engineering of proteases and CRISPR-Cas systems, development of new types of sensors, and new materials for biomedical applications.
Carlos RinaldiDepartment Chair and Dean’s Leadership Professor
MY GROUP STUDIES THE BEHAVIOR AND BIOMEDICAL APPLICATIONS OF MAGNETIC NANOPARTICLES. We combine expertise in synthesis and surface modification of magnetic nanoparticles, physical, chemical, and magnetic characterization, and modelling to understand the colloidal behavior of magnetic nanoparticles, their interaction with biological entities, and to advance their biomedical applications. We are actively investigating novel methods of synthesizing nanoparticles with tailored magnetic properties, evaluating nanoparticle stability and mobility in biological environments, and advancing applications of magnetic nanoparticles in cancer therapy and magnetic particle imaging.
Magnetic particle imaging (MPI) is a new biomedical imaging modality that enables unambiguous, tomographic, and quantitative evaluation of the distribution of magnetic nanoparticles in living subjects. We engineer biocompatible nanoparticle tracers for MPI that offer unprecedented resolution and sensitivity and can be used to track immune cells or image the distribution of biomarkers in pre-clinical models of cancer. We also engineer the surface of tracers to label cells of the innate and adaptive immune system for sensitive and quantitative tracking of their biodistribution. We collaborate with clinicians and other scientists to evaluate the application of MPI for tracking adoptive cell transfer immunotherapies. Students in my group become experts in nanoparticle synthesis, characterization, and evaluation for biomedical applications through highly collaborative, interdisciplinary research projects.
Ph.D., Massachusetts Institute of Technology, 2002
M.S.C.E.P., Massachusetts Institute of Technology, 2001
M.S., Massachusetts Institute of Technology, 2001
B.Sc., University of Puerto Rico, Mayagüez, 1998
Awards & Distinctions
- Fellow, American Institute for Medical and Biological Engineering (AIMBE), 2020
- University of Florida Term Professors, 2017-2020
- Charles A. Stokes Term Professor, University of Florida, 2015-2018
- International Journal of Nanomedicine Early Career Award, 2012
- Presidential Early Career Award for Scientists and Engineers (PECASE), 2006
- Lorena P. Maldonado-Camargo, Chuncheng Yang, and Carlos Rinaldi, “Scale-dependent rotational diffusion of nanoparticles in polymer solutions.” Nanoscale, 9(33):12039-12050, 2017. [doi:10.1039/C7NR01603D]
- Mythreyi Unni, Amanda Uhl, Shehaab Savliwala, Benjamin Savitzky, Roham Dhavalikar, Nicolas Garraud, David Arnold, Lena Kourkoutis, Jennifer Andrew, and Carlos Rinaldi, “Thermal decomposition synthesis of iron oxide nanoparticles with diminished magnetic dead layer by controlled addition of oxygen.” ACS Nano, 11(2):2284-2303, 2017. [doi: 10.1021/acsnano.7b00609]
- Lorena P. Maldonado-Camargo and Carlos Rinaldi, “Breakdown of the Stokes-Einstein relation for the rotational diffusivity of polymer grafted nanoparticles in polymer melts.” Nano Letters, 16:6767-6773, 2016. [doi: 10.1021/acs.nanolett.6b02359]
- Camilo Velez, Isaac Torres-Díaz, L.P. Maldonado-Camargo, Carlos Rinaldi, and David P. Arnold, “Magnetic assembly and crosslinking of nanoparticles for releasable magnetic microstructures.” ACS Nano, 9(10):10165-10172, 2015. [doi: 10.1021/acsnano.5b03783]
- Maribella Domenech, Ileana Marrero-Berrios, Madeline Torres-Lugo, and Carlos Rinaldi, “Lysosomal Membrane Permeabilization by Targeted Magnetic Nanoparticles in Alternating Magnetic Fields.” ACS Nano, 7(6):5091-5101, 2013. [doi: 10.1021/nn4007048]
- Mar Creixell, Ana C. Bohorquez, Madeline Torres-Lugo, and Carlos Rinaldi, “EGFR-targeted magnetic nanoparticle heaters can kill cancer cells without a perceptible temperature rise.” ACS Nano, 5(9), 7124-7129, 2011. [doi: 10.1021/nn201822b]