skip to Main Content
Tanmay Lele, Ph.D.
Charles A. Stokes Professor

Areas of Interest

Cell mechanics
Cell and tissue engineering
Quantitative cell biology
Cells in our body perform complex tasks, including movement across tissues, adhesion to polymeric scaffolds in the body and the sensing of chemical and mechanical signals. These complex processes depend in large part on the intracellular cytoskeleton. Specialized 'motor' proteins that convert chemical energy into mechanical work associate and move along the polymeric cytoskeleton enabling critical cell functions including intracellular mechanical force generation. We are interested in how the cytoskeleton and associated motor proteins generates forces inside the living cell. This work has applications in understanding diseases of the cardiovascular and muscular system, as well as cancer. We are also developing new biomaterials and nanotechnologies for characterizing and controlling cellular forces.


UF Research Foundation Professorship, 2019
Charles A. Stokes Professorship, 2018-
College of Engineering Doctoral Mentoring Award, 2018
UF Term Professorship, 2017-
UF Provost’s Excellence Award for Assistant Professors, 2012
Technology Innovator Recipient, UF Office of Technology Licensing, 2011
National Science Foundation CAREER Award, 2010
National Scientist Development Grant (American Heart Association), 2007


Postdoctoral Fellow, Vascular Biology, Harvard Medical School/Children’s Hospital, Boston MA, 2002-2006
Ph.D., Chemical Engineering, Purdue University, West Lafayette, 2002
B.Chem. Eng., UDCT, Mumbai, India 1998

Courses Taught

Chemical Kinetics and Reactor Design
Introduction to Biomolecular Engineering
Dynamics of Cellular Processes
Material and Energy Balances
Chemical Engineering Kinetics

Selected Publications

  • Zhang, Q., Narayanan, V., Mui, K.L., O’Bryan, C.S., Anderson, R.H., Birendra, K.C., Davis, J.I., Denis, K.B., Antoku, S., Roux, K.J., Dickinson, R.B., Angelini, T.E., Gundersen, G.G, Conway, D.E., Lele,T.P., (2019), Mechanical stabilization of the glandular acinus by linker of nucleoskeleton and cytoskeleton complex, Current Biology. 2019 Sep 9;29(17):2826-2839
  • Agrawal, A., Lele, T.P., (2019) Mechanics of the nuclear membranes, Journal of Cell Science., 2019 Jul 15;132(14).
  • Lele, T.P., Dickinson, R.B., and Gundersen, G.G., Mechanical principles of nuclear shaping and positioning, Journal of Cell Biology, 2019, 217(10):3330-3342
  • Li, Y., Lovett, D., Zhang, Q., Neelam, S., Kuchibhotla, R.A., Zhu, R., Gundersen, G.G., Lele, T.P., and Dickinson, R.B.. Moving cell boundary drives nuclear flattening during cell spreading, Biophysical Journal, 2015, 109 (4), 670-686
  • Neelam, S., Chancellor, T.J., Li, Y., Nickerson, J., Roux, K., Dickinson, R.B., and Lele, T.P.  A direct force probe reveals the mechanics of nuclear homeostasis in the mammalian cell, Proceedings of the National Academy of Sciences, 2015, vol 112, no.18, 5720-5725.

Back To Top