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Piyush K. Jain, Ph.D.

Piyush K. Jain

Assistant Professor

Areas of Interest

Gene Editing
Nucleic acids & Protein Engineering
Responsive Systems
Jain’s NanoBiomolecular Precision Lab engineers new biomolecular systems to improve precision and delivery of genome editing tools including CRISPR/Cas systems. His lab chemically modifies DNA for understanding epigenetics and develops biomolecular nanosystems to deliver nucleic acids and proteins to the desired tissues. Jain’s research aims to diagnose and treat genetic disorders including cancer.



Ph.D., 2013, University of Missouri-Kansas City
B.Pharm., 2006, Dr. Hari Singh Gour University (Central University)

Courses Taught

Selected Publications

  • P. K. Jain and S. H. Friedman. The ULTIMATE Reagent: A Universal Photocleavable and Clickable Reagent for the Regiospecific and Reversible End Labeling of Any Nucleic Acid. ChemBioChem 2018; 19, 1264.
  • Jain PK, Ramanan V, Schepers AG, Dalvie N, Panda A, Fleming HE and Bhatia SN. Development of light-activated CRISPR using photocleavable protectors of guide RNAs. Angewandte Chemie International Edition, 2016; 55, 12440.
  • Sarode BR, Jain PK and Friedman SH. Polymerizing Insulin with Photocleavable Linkers to Make Light-Sensitive Macropolymer Depot Materials. Macromolecular Bioscience, 2016; 16 (8): 1138-1146.
  • Dudani JS, Jain PK, Kwong GA, Stevens KR and Bhatia SN. Photoactivated Spatiotemporally-Responsive Nanosensors of in Vivo Protease Activity. ACS Nano, 2015; 9(12), 11708-11717.
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